Pritelivir Demonstrates Superior Efficacy in People Living with HIV with Refractory HSV in Phase 3 PRIOH-1

In a subgroup analysis of people living with HIV enrolled in PRIOH-1, pritelivir demonstrated superior lesion healing, achieving 61% complete ...
Healio

Pritelivir shows promise against HSV in immunocompromised patients

DENVER — Pritelivir, an investigational antiviral drug for herpes simplex virus, demonstrated “superior efficacy” in healing lesions in immunocompromised patients, according to results of a phase 3 ...

Nuclear speckles play a key role in the progression of viral infection, research reveals

Herpes simplex virus type 1 (HSV-1) infection dramatically remodels the host cell's nuclear structures. Infection leads to the formation of viral replication compartments and to chromatin ...

GARM Clinic Introduces HSV Immunotherapy Protocol to Help Patients Break the Cycle of Recurrent Outbreaks

Three-phase treatment offers patients with HSV infections an alternative to perpetual antiviral management ROATAN, BAY ...
Medscape

Surge in Neonatal Herpes Simplex Virus Infections in the UK, With High Mortality

The incidence of neonatal herpes simplex virus (HSV) infections in the UK and Ireland increased dramatically over 15 years, and outcomes remained poor, with mortality and long-term neurologic ...
EurekAlert!

Targeting viral enzymes to strengthen brain immunity against HSV-1

Inhibiting the herpes simplex virus type 1 viral enzyme uracil-DNA glycosylase reactivates the natural defense protein apolipoprotein B mRNA editing enzyme, catalytic polypeptide-1 (APOBEC1) in the ...
Nasdaq

Assembly Biosciences Presents New Data Highlighting Long-Acting Herpes Simplex Virus Candidate ABI-5366 and Genital Herpes Prevalence and Treatment Patterns at the 2025 ESCMID ...

– ABI-5366 is currently being evaluated in ongoing Phase 1b clinical trial with interim proof-of-concept data expected in fall 2025 – SOUTH SAN FRANCISCO, Calif., April 09, 2025 (GLOBE NEWSWIRE) -- ...
Technology Networks

Viruses Hijack Tiny Nuclear Hubs To Spread Infection

Researchers found that Herpes simplex virus type 1 reorganizes nuclear speckles, essential sites for RNA processing. Without intact speckles, viral messenger RNAs cannot exit the nucleus, limiting ...